Brain stimulation reward (BSR) research seems focused mainly on understanding the anatomy, chemical contingiencies and optimal stimulation parameters of the circuit, and less on developing operant conditioning protocols. Authors like Burgess et al (1991), Garner et al (1991), Talwar et al (2002), Hermer-Vasquez et al (2005), who use BSR to generate specific, useful behaviors, are, at the moment, in minority. The limits and potential usefulness of complex operational conditioning by BSR remain largely unexplored.
Brain stimulation reward (BSR)
Medial forebrain bundle (MFB)
Waraczynski (2006) The central extended amygdala network as a proposed circuit underlying reward valuation. University of Wisconsin-Whitewater. Review suggesting that the anatomical substrate of BSR is largely contained in the extended amygdala.
Waraczynski (2008) GABA receptor agonism in the sublenticular central extended amygdala impairs MFB self-stimulation but GABA blockade does not enhance it. University of Wisconsin - Whitewater.
Ludvig et al (2007) The effects of reinforcer magnitude on timing in rats. University of Alberta.
Spiller et al (2008) The selective dopamine D(3) receptor antagonists SB-277011A and NGB 2904 and the putative partial D(3) receptor agonist BP-897 attenuate methamphetamine-enhanced BSR in rats. National Institute on Drug Abuse.
Kentner (2007) Investigating the hedonic effects of interferon-alpha on female rats using BSR. University of Ottawa. Using BSR to investigate the hedonic impact of a cytokine cancer treatment (no effect).
Schulteis & Liu (2006) Brain reward deficits accompany withdrawal (hangover) from acute ethanol in rats. UC San Diego School of Medicine, VA San Diego Healthcare System. Alcohol intoxication attenuates BSR efficiency.
Bespalov (2006) Lowered BSR thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists. IP Pavlov Medical University.
Waraczynski & Bemco (2006) Lidocaine inactivation of the ventral pallidum affects responding for BSR more than it affects the stimulation's reward value. University of Wisconsin at Whitewater. Inactivation of the ventral pallidum reduces maxium behavioural BSR response. Sometimes.
Kornetsky & Bain (1992) BSR: a model for the study of the rewarding effects of abused drugs. Boston University School of Medicine.
Milner (1991) BSR: a review. McGill University.