Brain stimulation reward (BSR)
Medial forebrain bundle (MFB)
Ventral tegmental area (VTA)
Nucleus accumbens (NAcc)
Mauge et al (2005) Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of BSR in rats. Harvard Medical School.
Fulton et al (2006) Potentiation of BSR by weight loss: Evidence for functional heterogeneity in brain reward circuitry. Concordia University. BSR is potentiated by chronic food restriction, but this effect depends on the exact site of stimulation along the MFB.
Eiler et al (2007) Responding for brain stimulation reward in the bed nucleus of the stria terminalis in alcohol-preferring rats following alcohol and amphetamine pretreatments. Indiana University-Purdue University at Indianapolis. Rats bred to prefer alcohol are sensitive to RBS in a new region of the basal ganglia.
Morissette & Boye (2008) Electrolytic lesions of the habenula attenuate brain stimulation reward. University of Montreal. Electrolytic lesions (?!) of the habenula (thalamic region that projects to midbrain monoamine nuclei) attenuates RBS in posterior lateral hypothalamus, VTA, dorsal and median raphe nuclei.
Miguelez & Bielajew (2004) Mapping the neural substrate underlying BSR with the behavioral adaptation of double-pulse methods. University of Ottawa.
Valchou et al (2006) Effects of endocannabinoid neurotransmission modulators on brain stimulation reward. University of Crete, Eli Lilly. Cannabinoids attenuate BSR.
Lassen et al (2007) BSR is integrated by a network of electrically coupled GABA neurons. Brigham Young University, University of New Mexico, Western University of Health Sciences. Electrical coupling in a large network of GABA neurons is required for BSR.
Eiler et al (2006) Amphetamine lowers brain stimulation reward (BSR) threshold in alcohol-preferring (P) and -nonpreferring (NP) rats: regulation by D-sub-1 and D-sub-2 receptors in the nucleus accumbens. Indiana University-Purdue University at Indianapolis. Rats bred to prefer alcohol are no more sensitive to BSR curve-shift by DA agonists and antagonists.
Choi et al (2004) Simultaneous AMPA/kainate receptor blockade and dopamine D2/3 receptor stimulation in the nucleus accumbens decreases brain stimulation reward in rats. University of Texas, University of Alberta. AMPA and D2/3 receptor blockade in the NAcc must be simultaneous to attenuate BSR.