18 October 2008
38th annual Society for Neuroscience conference in 3 weeks, iPlants in clinical trials by 2015?
iPlants in clinical trials by 2015 say the FutureBlogger polls (poll 1 poll 2). With the recent FDA approval of transcranial magnetic stimulation (TMS) for depression and the very successful early studies using deep brain stimulation (DBS) to treat the same disorder, you start to wonder. IF the estimation is accurate we should be able to observe the idea developing in the neuroscientific community right now. Search for rewarding brain stimulation/brain stimulation reward/deep brain stimulation in the SfN database of abstracts submitted to the upcomming 38th Annual Society for Neuroscience Conference in Washington DC (Nov 15-19). Most of it seems to be biochemistry I don't understand. Maybe you do. Please let me know what you find. Just started going through them now. An example: a search for ICSS (intra cranial self stimulation) returns 15 abstracts: Endocannabinoid modulation of mesolimbic reward substrates; Evaluating operant contingencies of brain reward self stimulation in mice; Intraventricular serotonin does not affect the reward of ventral tegmental self-stimulation; Effect of mesocorticolimbic microinjections of the kappa-opioid agonist U50,488 on intracranial self-stimulation in rats; Both GABAB receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats; Biphasic effects of the kappa opioid receptor agonist salvinorin A on hedonic state; Susceptibility and resilience to the acute and long-term effects of chronic social defeat on anhedonia in rats: implications for a model of depressive disorders; Intracranial self-stimulation as a positive reinforcer to study impulsivity as measured in the probability discounting paradigm; Behavioral and electrochemical indices of afferent modulation of cue-evoked dopamine release in the nucleus accumbens; Effects of T-817MA on the nigrostriatal dopaminergic systems and spatial motor learning in MPTP-treaded mice; Inducible elevation of ΔFosB in striatal regions enhances cocaine-induced facilitation of intracranial self-stimulation (ICSS) in mice; Addiction-like reward dysfunction in obese rats; Orexin signaling in the insula regulates nicotine reinforcement; Anatomical specificity of morphine, but not amphetamine, potentiation of medial forebrain brain stimulation reward; Δ9-tetrahydrocannabinol or ACEA, but not by methanandamide, enhances electrical brain-stimulation reward in rats, likely by activation of cannabinoid CB1 receptors.