04 March 2008

Deep brain stimulation papers 1

Today's catch for the implant technology section.

Rossi et al (2007) An electronic device for artefact suppression in human local field potential recordings during deep brain stimulation. Journal of Neural Engineering 4, p96-106. This paper describes 'FilterDBS' - an algorithm for filtering out the DBS stimulus artefact so that LFP recordings can be made during DBS.

Motta & Judy (2005) Multielectrode microprobes for deep-brain stimulation fabricated with a customizable 3-D electroplating process. IEEE Transactions on Biomedical Engineering 52(5), p923-933. To facilitate long-term DBS of the small and inaccessible rat STN the authors describe a novel DBS implant. This is particularly relevant to iPlant research since monoamine nuclei are also very small and inaccessible, even in humans.

Nielsen et al (2007) Chronic subthalamic high-frequency deep brain stimulation in Parkinson's disease--a histopathological study. European Journal of Neuroscience 14(2), p132-138. Limited histopathological changes in the vincinity of DBS electrodes appear to be related to the electrode itself rather than electrical stimulation.

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